If a suspicious breast lump can be felt, but cannot be seen with mammography or ultrasound, the surgeon may have to surgically remove the lump in order to get a definitive diagnosis. Sometimes the surgeon may ask the radiologist to place a localizing wire into the area of the abnormality to help ensure that the suspicious abnormality is completely removed at the time of the operation. This technique is referred to as a “wire localized” breast biopsy. These surgical biopsies are performed in the operating room, are most comfortable with sedation in addition to local anesthetic, and they result in a formal wound on the breast. For these reasons, an open surgical biopsy is usually only performed if a needle biopsy cannot.